Plexr Overview

Plexr is neither a laser, radio scalpel, electrocoagulation, or any other radio frequency system. It would be a mistake to try to compare the Plexr mechanism with these three other technologies. Physically, “plasma” is defined as the fourth state of matter (next to solid, gas and liquid) and can be considered “liquid gas” according to physicists. It is actually ionized gas, where ions can move freely. The "ionized" term means that on the one hand, significantly large amounts of electrons are released, while the atoms and air molecules (oxygen and nitrogen) are torn apart by Plexr energy. This creates a bundled “energetic cloud” of microplasma, formed by various positively and negatively charged particles with an action radius that actually only sublimes the superficial components of the epidermis (keratinocytes) (comparable to “evaporation”). Sublimation is therefore the physical term for the direct transition from the solid to the gas state. This process is possible due to the electrical potential difference between the needle tip and the human tissue and a high induced temperature. However, despite the “heat” of the plasma energy beam, there is no excessive energy (heat) transfer to underlying skin layers. Plasma Exeresis (Plexr) is one of the few technologies that is able to effectively limit heat penetration with only sublimation of the upper epidermal layer. This without damaging the deeper skin structures.

Simultaneously with sublimation of the top layer of epidermis, there is also a process of gentle stimulation in the dermis. This is based on the action of very gentle and highly reduced and selective energy transfer that occurs after the collision of the microplasma beam with the skin.

These fine energy impulses provide an instant contraction of elastin fibres that shorten, thicken and reposition from horizontal to vertical position. The cumulative result of elastin fibre contraction will lead to a tightening and ultimately significant tightening of the dermal tissue.

All these mentioned phenomena together for the most part provide the answer to the question “how does Plexr actually work”? In brief :

  • Reduction and tightening of epidermal skin by sublimation effect.

  • Tightening of the dermal tissue due to the contraction of elastic fibres.

  • Skin thickening due to collagen production (soft type 1)

  • Skin rejuvenation through increased angiogenesis, proliferation and migration of fibroblasts and normalization of keratinocyte mitosis.

During the treatment there is visible smoke as a result of the sublimation process. Thanks to the very superficial action of this particular Plexr microplasma, the subsequent scabs on the treated area will fall off in about a week, without bruising or scarring.


The safety of the Plexr treatment is immediately apparent: action is purely on the epidermis and does not reach the epidermal basal layer. There is no passage of electricity and no thermal damage. For example, in periorbital rejuvenation treatments, there is no damage to the optic nerve or adjacent areas, due to the precise and targeted action and the absence of leakage currents.

Plexr applications in dermatology and aesthetics: periorbital rejuvenation (upper - lower eyelid, so-called “non-surgical blepharoplasty”), “crow's feet” wrinkles, forehead tightening with eyebrow lift. Perioral rejuvenation (barcode), neck wrinkles and flaccidity, cheek wrinkles (micropeeling), genital rejuvenation, removal of discoloration (hyperpigmentation or hypopigmentation), treatment of scars and acne (active and inactive phase), stretch marks and scars (especially hypertrophic) treatment in combination with other treatments, removal of tattoos and micro-pigmentations (difficult to treat with other techniques on sites such as lips, eyelids, eyebrows, etc.) and elimination of benign skin lesions (warts, fibroids, keratosis, xanthelasma, etc.).

Differences between Plexr and equipment based on radio frequency power:


Radio-scalpel, electro-coagulation, or radio-frequency equipment with electromagnetic current as the operating mechanism, uses the body as part of the circuit and works by cutting and / or coagulating, causing necrosis of wound walls, diffuse inflammation, bruising or scarring in some cases. Potential thermal damage from radio frequency based equipment is difficult to control because the current is naturally conducted through the tissues as well as the fluid components of the body. Particularly important for the safety aspect, the low resistance of the nerve endings (optic nerve) must determine the strength of electrical flow. This safe boundary line is almost always lower and is inconsistent with the electrical power of various radio frequency equipment, which often exceeds the safety limit several times. For these reasons, Plexr can be considered more versatile, more accurate, and above all, safer.

In fact, due to a substantially different method, it makes no sense to compare Plexr to radio scalpel based solely on the fact that they both perform skin excision.

Plexr is not a light


Laser works in a different way and on the basis of photons that are arranged in a coherent monochromatic and collimated light beam. This light energy is partially absorbed, refracted and reflected by the tissue, which is eventually converted into mechanical, thermal or chemical energy. There is a rise in temperature on the skin surface but also in the underlying layers. This so-called thermal effect results, among other things, in the formation of new collagen. However, when the thermal effect becomes excessive, it can cause damage to the skin in the form of burns and scar formation.


Plexr offers the ability to work on any tissue, including in areas at risk (conjunctiva eye, mucosa, cartilage, hairy skin) without the risk of scarring or damaging neighboring tissues. Any skin type, regardless of melanin level, can be treated. For skin of phototypes IV and above, it is advisable to use a melanogenesis-inhibiting cream (such as Hydroquinone) on the area to be treated prophylactically one to two weeks before the treatment to prevent possible and temporary discoloration.

Plexr is not a laser


In Erbium lasers, water acts as the primary chromophore. The laser effects on the skin are created by the evaporation of water. On some skin types with a thick horny layer or hyperkeratotic skin lesions, the laser cannot show those effects without a very high thermal damage risk. In contrast to the lasers, Plexr acts on both good and bad conductors by sublimation (from the solid state to the gas state without the intervention of the liquid state), regardless of the moisture content of the skin. The differences between Plexr and laser: Plexr produces no thermal damage in unwanted areas, the recovery time is shorter because there is no inflammation, less difference between treated areas and less chance of discoloration (hyper- or hypopigmentation).

Plexr is therefore not a laser, not a radio scalpel or radio frequency device, but a device that generates plasma in the unique form Exeresis. Plexr is very safe, accurate and non-invasive. Plexr is not warm in deeper skin layers and acts exclusively on the patient's superficial skin, without crossing the basal lamina or causing damage to the dermis.

Plexr is an innovative and internationally patented technology (protected against counterfeiting with two international patents) invented and created by a group of Italian medical researchers, during years of research and study, and developed by the GMV company of Rome.

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